LOS ANGELES (AP) — Vaccinations against COVID-19 have begun in California amid a huge surge in infections and hospitalizations.

Intensive care unit nurse Helen Cordova received a shot of the Pfizer vaccine Monday at Kaiser Permanente Los Angeles Medical Center.

Gov. Gavin Newsom tweeted that Cordova was one of the first Californians to be vaccinated. The first shipments of the Pfizer vaccine left Michigan early Sunday for 145 distribution centers nationwide.

California’s initial batch was scheduled to total 325,000 doses arriving over several days. Newsom said another 400,000 doses would arrive next week.