The Senate approved a budget resolution early Friday that would allow for the passage of Biden's $1.9 trillion COVID-19 relief package without Republican support.
Harris broke a 50-50 tie in the Senate by casting a vote in favor of the Democratic measure, which was approved by the House of Representatives on Wednesday. The resolution now goes back to the House for final approval.
Biden has said he hopes to garner Republicans' support for his relief package, billed as the American Rescue Plan, though Democrats are working to push it through Congress with or without the GOP.
Earlier this week, the president met with Republican senators to discuss the package in an effort to generate bipartisan support.